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Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin.

Monitor closely for neurologic symptoms during the first several months of therapy.

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These recommendations included setting a baseline Hb level at which to initiate ESA therapy in asymptomatic patients, reassessing anemia at the start of each new chemotherapy regimen, restricting ESA use to certain tumor types, further restrictions to ESA indications on the US Food and Drug Administration-approved label, and the conduct of future clinical trials.

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Because only certain cancers will respond to imatinib, it is prescribed only for patients identified by specific diagnostic tests (for example, the Philadelphia chromosome abnormality test).

CKD) is a reduction in erythropoietin production due to kidney damage.

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Differences between the 2002 and 2007 guideline recommendations appear in italicized text.

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During the treatment with Recombinant Human Erythropoietin Alfa, iron concentration in serum usually decreases.

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To quantify the level of proteinuria, rather than using a 24-hour urine collection, the determination of the protein-to-creatinine or albumin-to-creatinine ratio in a random urine specimen is recommended.

The DPM now reports serum potassium levels as well as the use of potassium-binding resins (e.

Several of these may interplay to cause anemia eventually.