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Like dofetilide and quinidine, ranolazine caused an increase in both ERD 30% and LRD 30% ().
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Interestingly, if de novo ceramide production was prevented via inhibition of serine palmitoyltransferase, elevated fatty acid β-oxidation rates were normalized with a complete restoration of glucose oxidation rates in mice with a cardiac overexpression of glycosylphosphatidylinositol-anchored human LPL ().
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It is possible that all of these findings in vitro were affected by nonphysiological conditions of substrate and oxygen supply.
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Hz, left) in a representative cell measured in the presence of 10 μM ranolazine compared with the CTR.
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Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.
Patterns of coronary heart disease mortality over the 20th century in England and Wales: Possible plateaus in the rate of decline.
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Ranolazine increased the effective refractory period, induced post-repolarization refractoriness, and caused a loss of excitability of the tissue at higher pacing rates in atrial tissue (Antzelevitch et al.
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In one embodiment, the oral dose of ranolazine is provided for in a tablet.
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Anti-ischemic effects and long-term survivial during ranolazine monotherapy in patients with chronic severe angina.
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As a consequence, elevated diastolic calcium levels activate contractile proteins even during diastole leading to diastolic dysfunction.
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Sponsorship and oversight of the trial were provided by the Department of Veterans Affairs Cooperative Studies Program, with additional funding from the Canadian Institutes of Health Research.
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Before assessing the effect of ranolazine in reducing cancer cell invasiveness, we addressed a possible cytotoxic effect of its application.
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The present study presents evidence of a potent effect of the combination of ranolazine and dronedarone to eliminate both the trigger and substrate associated with the initiation and maintenance of AF.
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In another aspect, the invention is directed to a method for reducing or preventing torsades de pointes ventricular tachycardia in a patient in need thereof, said method comprising coadministering to the patient synergistically therapeutic amounts of dronedarone and ranolazine or pharmaceutically acceptable salt or salts thereof.
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The rehabilitation team may include the following professionals who work closely with the patient: exercise physiologists, occupational therapists, and physical therapists.
However, restenosis develops in only a minority of patients who receive bare-metal stents, and angina develops in only some of those patients (11% of the patients in our trial who were treated with PCI underwent a repeat procedure within 12 months).
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This combination therapy incorporates both rhythm and rate control.
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An increase in AMPK activity has also been observed with cardiac hypertrophy in the rat, illustrating that there is not a simple switch to fetal metabolic regulation in response to chronic cardiac stress ().
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Nevertheless, additional investigations of the mechanism underlying our observations are needed to corroborate a clinically meaningful effect of ranolazine on glucose homeostasis in humans.
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Ranolazine is an anti-ischemic and antianginal agent that has been shown in preclinical and clinical studies to inhibit the late sodium current (I Na) and improve diastolic relaxation.
If ranolazine's beneficial mechanism of action is related to prevention of ischemia-induced reduction in myocardial blood flow, then ranolazine's anti-ischemia effects should become evident only once ischemia has developed and should become more marked, compared with placebo, as exercise and ischemia progresses.
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Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species.
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The multilayer tablets and capsules suitable for use in the present invention can be fabricated using methods known in the art using standard machinery.
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It is important to mention that in the study by Wyatt et al ranolazine was shown to be a weak inhibitor of complex I when compared with rotenone or amobarbital, especially in energetically coupled mitochondria.
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These mechanisms have harmful effects on the contractility and efficiency of the heart.
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The results of the present study confirm that ERD 30% and LRD 30% are indeed sensitive markers of hERG block from dofetilide, quinidine, and ranolazine.
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Anti-anginal efficacy and safety were similar in both groups, but ranolazine reduced hemoglobin A1c levels in diabetics compared to placebo (0.
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Late, ranolazine interrupts the vicious cycle between ischemia and diastolic dysfunction.
Eight subjects, all healthy male volunteers aged between 18 and 40 entered and all completed the study and were available for pharmacokinetic and safety analysis.
Furthermore, this study using ranolazine, a drug that is clinically used, shows that the pharmacological inhibition of Na V channels could be effective in reducing metastastic colonisation with no apparent toxic effect.
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